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The enzyme stabilizes the thiolate anion at neutral pH and combines this capability with providing a binding pocket for hydrophobic electrophiles at a site adjacent to the bound GSH 15

Proteins that bind to glutathione, such as GST, can be purified using glutathione agarose

IP6K3, located near the major histocompatibility complex, has previously been linked to other autoimmune diseases such as Graves disease and rheumatoid arthritis, indicating its potential role in the development of autoimmunity and HT [20]

The majority of the mitochondrial pool of folate is THF and 10-formyl-THF with less than 10% being 5-methyl-THF and 5-formyl-THF